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Positron emission tomography/computed tomography: diagnostic accuracy in lymphoma
Author(s) -
HernandezMaraver Dolores,
HernandezNavarro Fernando,
GomezLeon Nieves,
Coya Juan,
RodriguezVigil Beatriz,
Madero Rosario,
Pinilla Immaculada,
MartinCurto Luis M.
Publication year - 2006
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2006.06284.x
Subject(s) - medicine , positron emission tomography , lymphoma , mcnemar's test , nuclear medicine , radiology , pet ct , stage (stratigraphy) , tomography , positron emission tomography computed tomography , pathology , paleontology , statistics , mathematics , biology
Summary An accurate initial staging of patients with non‐Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) is critical for the selection of an appropriate treatment. Computed tomography (CT) remains the standard imaging technique, although it is based on anatomic criteria. Positron emission tomography (PET) with 2‐deoxy‐2‐[fluorine‐18]fluoro‐ d ‐glucose (FDG) provides useful functional information but requires anatomical correlation to localise lesions accurately. We have prospectively compared the accuracy of combined PET/CT with that of CT and PET alone at initial staging in lymphoma patients. Forty‐seven newly diagnosed patients were evaluated. PET/CT was superior compared with CT and PET in nodal evaluation and detection of extranodal disease. Using a staging algorithm with PET/CT resulted in the disease stage being increased in 11 of 47 patients (10 NHL and 1 HL) (McNemar test P = 0·012). Therefore, a different treatment strategy based on PET/CT findings was suggested for seven patients (14·8%). PET/CT markedly improves accuracy in the diagnostic work‐up of patients with lymphoma.