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Significant increase of CKS1B amplification from monoclonal gammopathy of undetermined significance to multiple myeloma and plasma cell leukaemia as demonstrated by interphase fluorescence in situ hybridisation
Author(s) -
Chang Hong,
Yeung Joanna,
Xu Wei,
Ning Yi,
Patterson Bruce
Publication year - 2006
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2006.06237.x
Subject(s) - monoclonal gammopathy of undetermined significance , plasma cell dyscrasia , multiple myeloma , fluorescence in situ hybridization , plasma cell neoplasm , plasma cell , plasma cell leukemia , pathology , microbiology and biotechnology , monoclonal , medicine , cancer research , plasmacytoma , biology , monoclonal antibody , immunology , antibody , immunoglobulin light chain , genetics , gene , chromosome
Summary The genetic events that lead to tumour progression in plasma cell dyscrasia are not well understood. Interphase cytoplasmic fluorescence in situ hybridisation was used to investigate the CKS1B amplification status (at 1q21) in clonal plasma cells from 123 patients: 23 monoclonal gammopathy of undetermined significance (MGUS), 75 multiple myeloma (MM) and 26 plasma cell leukaemia (PCL). While CKS1B amplification was absent in MGUS patients, such amplification (3–8 copies) was detected in 36% of newly diagnosed MM, 52% relapsed MM and 62% PCL ( P < 0·001). Our results suggest that CKS1B amplification is associated with transformation from MGUS to MM and progression to PCL.