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Platelet‐dependent thrombography: a method for diagnostic laboratories
Author(s) -
Dargaud Yesim,
Luddington Roger,
Baglin Trevor
Publication year - 2006
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2006.06188.x
Subject(s) - thrombin generation , thrombin , platelet , tissue factor , chemistry , platelet activation , medicine , immunology , coagulation
Summary The thrombin‐platelet feedback loop was examined at low concentration tissue factor using calibrated automated thrombography in combination with the elimination of contact factor activation by corn trypsin inhibitor. The results indicated that, when contact factor activation was eliminated, the thrombin‐platelet feedback loop was a major determinant of thrombin generating capacity and that platelets had a greater role in regulating the propagation of thrombin generation than its initiation. This method has potential application to the measurement of platelet‐dependent thrombin generation in clinical diagnostic laboratories and hence the investigation of patients with apparent hypo‐ or hypercoagulable phenotypes.