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Fetal hepatic haematopoiesis is modulated by arterial blood flow to the liver
Author(s) -
Kunisaki Shaun M.,
Azpurua Humberto,
Fuchs Julie R.,
Graves Sara C.,
Zurakowski David,
Fauza Dario O.
Publication year - 2006
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2006.06183.x
Subject(s) - haematopoiesis , fetus , blood flow , medicine , common hepatic artery , artery , ligation , hemodynamics , endocrinology , pathology , biology , stem cell , pregnancy , genetics
Summary We describe an as yet unrecognised relationship between fetal hepatic haematopoiesis and arterial blood flow to the liver. To increase hepatic arterial flow, the common bile duct (CBD) was ligated in fetal lambs. Reduction of hepatic arterial flow was accomplished in age‐matched animals by hepatic artery (HA) ligation. Multiple analyses performed before term showed a significant increase in haematopoietic cell density in CBD animals when compared with sham controls and HA animals. In contrast, HA animals demonstrated a decrease in liver haematopoietic activity. Fetal hepatic haematopoiesis is dependent upon arterial blood flow to the liver.