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Serial determination of FLT3 mutations in myelodysplastic syndrome patients at diagnosis, follow up or acute myeloid leukaemia transformation: incidence and their prognostic significance
Author(s) -
Georgiou Georgios,
Karali Vasiliki,
Zouvelou Christina,
Kyriakou Elias,
Dimou Maria,
Chrisochoou Stamatis,
Greka Paraskevi,
Dufexis Dimitrios,
Vervesou Elisavet,
Dimitriadou Evaggelia,
Efthymiou Anna,
Petrikkos Loizos,
Dima Katerina,
Lilakos Konstantinos,
Panayiotidis Panayiotis
Publication year - 2006
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2006.06171.x
Subject(s) - medicine , incidence (geometry) , myelodysplastic syndromes , myeloid , bone marrow , oncology , gene mutation , mutation , fms like tyrosine kinase 3 , gene , genetics , biology , physics , optics
Summary The incidence of FLT3 mutations (internal tandem duplication and Asp835) was investigated in bone marrow samples from 97 patients with myelodysplastic syndrome [(MDS); excluding cases with refractory anaemia with excess blasts in transformation] at the time of diagnosis and several time points thereafter. Three patients had FLT3 mutations at presentation. Forty‐two patients progressed to acute myeloid leukaemia (AML), including the three patients with FLT3 mutations at MDS diagnosis. Three additional patients acquired FLT3 mutations and progressed to AML in 1 month. FLT3 mutations seem to be a critical additional genetic event that transforms a minority of MDS patients to AML.