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Polymorphisms in innate immunity genes and risk of non‐Hodgkin lymphoma
Author(s) -
Forrest Matthew S.,
Skibola Christine F.,
Lightfoot Tracy J.,
Bracci Paige M.,
Willett Eleanor V.,
Smith Martyn T.,
Holly Elizabeth A.,
Roman Eve
Publication year - 2006
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2006.06141.x
Subject(s) - innate immune system , immunology , lymphoma , odds ratio , biology , allele , immune system , immunity , population , toll like receptor , gene , medicine , genetics , environmental health
Summary Genetic variation in innate immunity may alter host‐pathogen defence mechanisms and promote aberrant immune responses and non‐Hodgkin lymphoma (NHL). To test this hypothesis, we investigated polymorphisms in innate immune genes in a pooled analysis of two population‐based case‐control studies of NHL from the San Francisco Bay Area (308 cases, 684 controls) and UK (596 cases, 758 controls). The caspase recruitment domain‐containing protein 1007fs homozygote variant was positively associated with NHL risk (odds ratios (OR) = 3·1, 95% confidence intervals (CI) 1·1–8·8), whereas the toll‐like receptor 4 1063A>G variant allele was inversely associated with diffuse large cell lymphoma (OR = 0·67, 95% CI 0·45–0·99). These results suggest that variation in innate immune genes may alter NHL susceptibility.