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The status of new anticoagulants
Author(s) -
Bates Shan M.,
Weitz Jeffrey I.
Publication year - 2006
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2006.06134.x
Subject(s) - medicine , intensive care medicine
Summary Currently available anticoagulants include heparin, low‐molecular weight heparin, fondaparinux and warfarin. Despite advances with low‐molecular weight heparin and fondaparinux, the currently available agents have limitations that have provided the impetus for the development of new drugs for prevention and treatment of both venous and arterial thromboembolism. Novel anticoagulants targeting specific steps in coagulation are in various stages of development. This paper reviews the pharmacology of these new agents and describes the results of clinical trials with new anticoagulants in more advanced stages of clinical testing.