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Allogeneic haematopoietic cell transplantation from alternative donors with a conditioning regimen of low‐dose irradiation, fludarabine and cyclophosphamide in Fanconi anaemia
Author(s) -
Yabe Hiromasa,
Inoue Hiroyasu,
Matsumoto Masae,
Hamanoue Satoshi,
Koike Takashi,
Ishiguro Hiroyuki,
Koike Hideki,
Suzuki Kazuo,
Kato Shunichi,
Kojima Seiji,
Tsuchida Masahiro,
Mori Tetsuya,
Adachi Souichi,
Tsuji Koichiro,
Koike Kenichi,
Morimoto Akira,
Sako Masahiro,
Yabe Miharu
Publication year - 2006
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2006.06128.x
Subject(s) - fludarabine , cyclophosphamide , medicine , transplantation , total body irradiation , regimen , haematopoiesis , surgery , chemotherapy , gastroenterology , stem cell , biology , genetics
Summary A pilot study was undertaken using a fludarabine‐based conditioning regimen to improve haematopoietic cell transplantation (HCT) from alternative donors in 27 Fanconi anaemia (FA) patients. Patients were conditioned with 150–180 mg/m 2 of fludarabine, 40 mg/kg of cyclophosphamide, 5–10 mg/kg of antithymocyte globulin, and 300–450 cGy of thoracoabdominal/total body irradiation. One patient who received unrelated cord blood transplantation failed to engraft, another patient died of sepsis. The 1‐year overall survival was 96·3% (95% CI, 89–100). This conditioning regimen exerted an immunosuppressive effect that enabled durable engraftment in alternative donor HCT without severe toxicity.