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Clinical relevance of cytogenetic abnormalities at diagnosis of acquired aplastic anaemia in adults
Author(s) -
Gupta Vikas,
Brooker Carol,
Tooze Jennifer A.,
Yi Qilong,
Sage Deborah,
Turner David,
Kangasabapathy Pamela,
Marsh Judith C. W.
Publication year - 2006
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2006.06105.x
Subject(s) - karyotype , monosomy , trisomy 8 , trisomy , abnormality , cytogenetics , clinical significance , aneuploidy , chromosome 7 (human) , aplastic anemia , medicine , chromosomal abnormality , pediatrics , pathology , gastroenterology , immunology , chromosome , biology , bone marrow , genetics , psychiatry , gene
Summary The outcome of 81 adult aplastic anaemia patients who had successful cytogenetics at diagnosis and received immunosuppressive therapy was evaluated. Ten patients had an abnormal karyotype, six of which had a trisomy. Four of five evaluable patients with a trisomy responded. One patient with monosomy 7 achieved a complete response and later developed haemolytic paroxysmal nocturnal haemoglobinuria but no recurrence of monosomy 7. None of the patients with a non‐numerical karyotypic abnormality responded. No significant differences in survival or later clonal disorders were observed between patients with a normal karyotype and those with an abnormal karyotype.