Premium
Mutations of the myeloid transcription factor CEBPA are not associated with the blast crisis of chronic myeloid leukaemia
Author(s) -
Pabst Thomas,
Stillner Erica,
Neuberg Donna,
Nimer Stephen,
Willman Cheryl L.,
List Alan F.,
Melo Junia V.,
Tenen Daniel G.,
Mueller Beatrice U.
Publication year - 2006
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2006.06057.x
Subject(s) - cebpa , myeloid , chronic myeloid leukaemia , transcription factor , cancer research , biology , mutation , clone (java method) , gene , genetics , medicine
Summary The transcription factor CEBPA is crucial for normal myeloid differentiation. CEBPA gene mutations have been reported in patients with acute myeloid leukaemia. The inevitable evolution of chronic myeloid leukaemia (CML) in chronic phase (CP) to a fatal blast crisis (BC) is assumed to result from the acquisition of additional genetic changes in the leukaemic clone. Gain of CEBPA mutations might represent a key event causing the differentiation block observed in myeloid CML‐BC, but not in CML‐CP. Here, no CEBPA mutation in 95 CML‐BC patients was found, suggesting a limited role, if any, of CEBPA mutations in this disorder.