Premium
A critical appraisal of the use of recombinant factor VIIa in acquired bleeding conditions
Author(s) -
Mittal Sajjan,
Watson Henry G.
Publication year - 2006
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2006.06023.x
Subject(s) - recombinant factor viia , factor viia , medicine , critical appraisal , recombinant dna , intensive care medicine , surgery , chemistry , pathology , coagulation , tissue factor , biochemistry , alternative medicine , gene
Summary Recombinant activated factor VII (rVIIa) was initially used for the treatment of inhibitors in patients with haemophilia. However, its localised mode of action at sites of damage to the vessel combined with dramatic clinical observations in exsanguinating patients have resulted in huge interest in its use as a global haemostatic agent. Although it appears safe, with no obvious excess of thrombotic events, its use in assorted acquired bleeding disorders, especially those associated with the development of complex coagulopathies, such as in the post‐trauma state, has proved to be less dramatic than hoped.