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High‐density mapping and follow‐up studies on chromosomal regions 1, 3, 6, 12, 13 and 17 in 28 families with chronic lymphocytic leukaemia
Author(s) -
Ng David,
Marti Gerald E.,
Fontaine Laura,
Toro Jorge R.,
Caporaso Neil,
Goldin Lynn R.
Publication year - 2006
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2006.05972.x
Subject(s) - linkage (software) , chronic lymphocytic leukemia , chromosome , lod score , genetic linkage , family aggregation , chromosomal region , genetics , medicine , biology , oncology , immunology , disease , gene mapping , gene , leukemia
Summary A subset of chronic lymphocytic leukaemia (CLL) shows familial aggregation. Studies show an increased risk for CLL and other lymphoproliferative disease among first‐degree relatives of affected individuals. A genome‐wide scan of 18 CLL families in 2003 detected LOD or non‐parametric linkage scores ≥1·0 on chromosomes 1, 3, 6, 12, 13 and 17. Follow‐up study with 28 families showed no evidence of linkage at 1p22.1–p21.2, 3q22.1, 3q26.2, 6q22.31–q23.2, 12q24.23, 14q32.13, 17p13.3. Chromosome 13q21.33 remains a region of interest with a P ‐value of 0·013 (marker D13S1291) and warrants additional molecular investigation as a susceptibility region for CLL.