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Immunohistochemical analysis of the antiapoptotic Mcl‐1 and Bcl‐2 proteins in follicular lymphoma
Author(s) -
Michels Jorg,
Foria Vipul,
Mead Ben,
Jackson Gill,
Mullee Mark,
Johnson Peter W. M.,
Packham Graham
Publication year - 2006
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2005.05954.x
Subject(s) - immunohistochemistry , follicular lymphoma , lymphoma , medicine , pathology , high power field
Summary In the present study, we investigated the expression of Mcl‐1 and Bcl‐2 by immunohistochemistry in 85 patients of grades 1–3 and transformed follicular lymphoma (FL). In lymphoma tissue, centroblasts uniformly expressed high levels of Mcl‐1 (Mcl‐1 hi ) whereas centrocytes demonstrated low Mcl‐1 expression (Mcl‐1 lo ). Bcl‐2 expression in centroblasts/centrocytes was reciprocal to Mcl‐1 staining in most cases. A high number of Mcl‐1 hi centroblasts in tissue sections (≥200/high‐power field) correlated with poor overall survival ( P < 0·001), independent of the International Prognostic Index and FL grade. This suggests that the number of centroblasts with strong Mcl‐1 staining is associated with clinical outcome in FL patients.