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Lineage involvement in chronic myeloid leukaemia: comparison between MBCR/ABL + and mBCR/ABL + cases
Author(s) -
Primo Daniel,
Sanchez Maria Luz,
Espinosa Ana Belén,
Tabernero María Dolores,
Rasillo Ana,
Sayagués Jose Ma,
Gonzalez Marcos,
Hernandez Jose Ma,
Orfao Alberto
Publication year - 2006
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2005.05944.x
Subject(s) - haematopoiesis , myeloid , abl , breakpoint cluster region , k562 cells , biology , cd34 , cancer research , immunology , microbiology and biotechnology , stem cell , leukemia , gene , genetics , tyrosine kinase , receptor
Summary The relationship between different Abelson / breakpoint cluster region ( BCR/ABL + ) gene rearrangements and the involvement of different haematopoietic cell lineages were investigated in 15 chronic myeloid leukaemia patients. Analysis of purified cell populations confirmed the involvement of the neutrophil (89%), monocytic (89%), eosinophil (88%), erythroid (100%), and CD34 + cells (100%) in virtually all patients, without differences between minor BCR/ABL + and major BCR/ABL + cases; BCR/ABL + B‐ and natural killer (NK)‐cells were detected in 43% and 31% of cases, respectively, whereas BCR/ABL + T‐cells were rare (7%). All three minor BCR/ABL + patients showed involvement of both B‐ and NK‐cells, which was infrequent (27%, P = 0·06 and 10%, P = 0·01) among major BCR/ABL + cases.