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Recurrent childhood anaplastic large cell lymphoma: a retrospective analysis of registered cases in Japan
Author(s) -
Mori Tetsuya,
Takimoto Tetsuya,
Katano Naoyuki,
Kikuchi Akira,
Tabuchi Ken,
Kobayashi Ryoji,
Ayukawa Hiroshi,
Kumagai Masaaki,
Horibe Keizo,
Tsurusawa Masahito
Publication year - 2006
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2005.05910.x
Subject(s) - medicine , retrospective cohort study , lymphoma , anaplastic large cell lymphoma , complete remission , surgery , hematology , transplantation , overall survival , hematopoietic stem cell transplantation , pediatrics , chemotherapy
Summary This report presents a retrospective study of 26 Japanese children with recurrent anaplastic large cell lymphoma. The first relapses were documented at a median of 10·5 months after the initial diagnosis. Twenty‐four patients achieved a second remission. After a median follow‐up period of 47 months, 18 patients are still alive: 15 patients are in second complete remission (CR), three patients are in third CR or later. The 5 year overall and relapse‐free survival rates were 61 ± 12% and 51 ± 12% respectively. The patients who received allogeneic haematopoietic stem cell transplantation during second CR showed a superior outcome to other patients.