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Circulating microparticles are elevated in haemophiliacs and non‐haemophilic individuals aged <18 years
Author(s) -
Proulle Valérie,
Hugel Bénédicte,
Guillet Benoit,
Grunebaum Lélia,
Lambert Thierry,
Freyssinet JeanMarie,
Dreyfus Marie
Publication year - 2005
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2005.05792.x
Subject(s) - phosphatidylserine , platelet , in vivo , coagulation , chemistry , thrombin , thrombin generation , membrane , andrology , medicine , immunology , biology , biochemistry , phospholipid , microbiology and biotechnology
Summary Platelet and cell stimulation lead to plasma membrane remodelling, resulting in phosphatidylserine (PS) externalisation in the outer leaflet of the membrane, associated with the shedding of PS‐rich microparticles (MPs), and contributes to thrombin generation by promoting the assembly of coagulation enzyme complexes. A previous study assessed MP levels in haemophiliacs after haemostatic treatment. To further investigate in vivo membrane remodelling, MP levels and characteristics were studied in 79 haemophiliacs and in 62 non‐haemophiliacs. Both groups showed heterogeneity in MP levels, with higher values in individuals <18 years. This finding should be considered when studying MP levels in individuals <18 years.