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Expression of the p75 neurotrophin receptor in acute leukaemia
Author(s) -
Beutel Gernot,
Meyer Johann,
Ma Liping,
Yin Songmei,
Eder Matthias,
Neuhoff Nils,
Wilkens Ludwig,
Wei Jing,
Hertenstein Bernd,
Heil Gerhard,
Schlegelberger Brigitte,
Ganser Arnold,
Li Zhixiong,
Baum Christopher
Publication year - 2005
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2005.05717.x
Subject(s) - receptor , nerve growth factor , cancer research , flow cytometry , haematopoiesis , neurotrophin , low affinity nerve growth factor receptor , immunology , biology , bone marrow , myeloid , medicine , microbiology and biotechnology , stem cell
Summary The dLNGFR is a cytoplasmically deleted form of the low‐affinity nerve growth factor receptor (LNGFR, also known as p75NTR). Recently, we observed a myeloid leukaemia in mice transplanted with dLNGFR‐modified bone marrow cells. Retroviral‐mediated expression of dLNGFR was suspected to contribute to the murine leukaemia. This led us to investigate the expression of p75NTR in human leukaemia. Expression of p75NTR was observed in nine of 119 (8%) adult patients with acute leukaemia by flow cytometry analysis, particularly in acute lymphoblastic leukaemia (26%). These results support further detailed analyses of neurotrophin receptors and downstream signalling pathways in haematological malignancies.