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Role of extracorporeal photochemotherapy in patients with refractory chronic graft‐ versus ‐host disease
Author(s) -
Rubegni P.,
Cuccia A.,
Sbano P.,
Cevenini G.,
Carcagnì M.R.,
D'Ascenzo G.,
De Aloe G.,
Guidi S.,
Guglielmetti P.,
Marotta G.,
Lauria F.,
Bosi A.,
Fimiani M.
Publication year - 2005
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2005.05586.x
Subject(s) - graft versus host disease , refractory (planetary science) , medicine , disease , host response , immunology , immune system , biology , astrobiology
Summary Recent studies suggest that extracorporeal photochemotherapy (ECP) may be beneficial in patients with steroid‐refractory chronic graft‐ versus ‐host disease (cGvHD). However, it is not yet clear whether certain conditions, such as age, mode of onset of cGvHD etc., influence clinical response and whether certain affected organs are more sensitive to ECP than others. We analysed the main clinical and laboratory parameters related to evolution of the disease in 32 steroid‐refractory cGvHD patients, to identify any useful response predictors to ECP. ECP affected the course of the disease positively in 78% (25/32) of our cases.