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Brain parenchymal damage after haematopoietic stem cell transplantation for severe sickle cell disease
Author(s) -
Woodard Paul,
Helton Kathleen J.,
Khan Raja B.,
Hale Gregory A.,
Phipps Sean,
Wang Winfred,
Handgretinger Rupert,
Cunningham John M.
Publication year - 2005
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2005.05491.x
Subject(s) - medicine , magnetic resonance imaging , transplantation , stem cell , parenchyma , pathology , hematopoietic stem cell transplantation , magnetic resonance angiography , radiology , haematopoiesis , disease , surgery , biology , genetics
Summary Prospective magnetic resonance imaging (MRI), magnetic resonance angiography (MRA), neuropsychological testing and neurological examinations were performed to determine the long‐term effect of successful haematopoietic stem cell transplantation on the neurological status of nine children with sickle cell disease. A scoring system for severity of brain parenchymal and vascular lesions was developed and applied. Neurological examinations and neuropsychometric tests were stable, but MRI and MRA studies were not. Transient changes occurred early in two patients. Persistent changes occurred in five. Parenchymal lesions occurred in zero of two patients without prior lacunae or infarcts and in all seven with prior lacunae or infarcts ( P = 0·0278).