Premium
Bone marrow endothelial cells in multiple myeloma secrete CXC‐chemokines that mediate interactions with plasma cells
Author(s) -
Pellegrino Antonio,
Ria Roberto,
Pietro Giulia Di,
Cirulli Teresa,
Surico Giammarco,
Pennisi Angela,
Morabito Fortunato,
Ribatti Domenico,
Vacca Angelo
Publication year - 2005
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2005.05443.x
Subject(s) - cxcl14 , chemokine , angiogenesis , cxc chemokine receptors , chemotaxis , stromal cell , interleukin 8 , ccl7 , bone marrow , cancer research , monocyte , immunology , chemistry , microbiology and biotechnology , cytokine , biology , ccl2 , cxcl10 , medicine , receptor , chemokine receptor , inflammation
Summary Bone marrow endothelial cells (EC) from patients with multiple myeloma (MM) were found to express and secrete higher amounts of the CXC‐chemokines CXCL8/interleukin (IL)‐8, CXCL11/interferon‐inducible T‐cell alpha chemoattractant (I‐TAC), CXCL12/stromal cell‐derived factor (SDF)‐1 α , and CCL2/monocyte chemotactic protein(MCP)‐1 than EC from human umbilical vein (HUVEC), considered as a healthy counterpart. Paired plasma cells and several MM cell lines expressed cognate receptors of each chemokine to a variable extent. When cells were exposed to chemokines, CXCL8/IL‐8 and CXCL12/SDF‐1 α stimulated their proliferation and all chemokines stimulated cell chemotaxis. It is suggested that angiogenesis also favours MM progression through the release of CXC‐chemokines.