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Interleukin 4, interleukin 6 and interleukin 10 polymorphisms in children with acute and chronic immune thrombocytopenic purpura
Author(s) -
Wu KangHsi,
Peng ChingTien,
Li TsaiChung,
Wan Lei,
Tsai ChangHai,
Lan ShouJen,
Chang MingCheng,
Tsai FuuJen
Publication year - 2005
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2005.05385.x
Subject(s) - thrombocytopenic purpura , immune system , immunology , genotype , interleukin , medicine , biology , cytokine , gene , genetics
Summary Immune thrombocytopenic purpura (ITP) is an immune‐mediated disorder. We investigated the polymorphisms of interleukin (IL)‐4 intron 3, IL‐6 (−572 G/C), and IL‐10 (−627 C/A) in 50 children with acute ITP, 30 children with chronic TIP, and 100 healthy individuals. There were significant differences in the RP1/RP2 genotype proportion ( P = 0·04) and the RP2 allelic frequency ( P = 0·03) of IL‐4 intron 3 and the A/C genotype proportion ( P = 0·01) of IL‐10 (−627) between children with chronic ITP and controls. This finding suggests that the IL‐4 intron 3 and IL‐10 (−627) polymorphisms contribute to the susceptibility of developing childhood chronic ITP.