Premium
Pilot study of reduced‐intensity conditioning followed by allogeneic stem cell transplantation from related and unrelated donors in patients with myelofibrosis
Author(s) -
Kröger Nicolaus,
Zabelina Tatjana,
Schieder Heike,
Panse Jens,
Ayuk Francis,
Stute Norbert,
Fehse Natalja,
Waschke Olga,
Fehse Boris,
Kvasnicka Hans Michael,
Thiele Jürgen,
Zander Axel
Publication year - 2005
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2005.05373.x
Subject(s) - myelofibrosis , medicine , transplantation , gastroenterology , fludarabine , surgery , hematopoietic stem cell transplantation , graft versus host disease , cyclophosphamide , chemotherapy , bone marrow
Summary A prospective pilot study was performed to evaluate the effect of reduced‐intensity conditioning with busulphan (10 mg/kg), fludarabine (180 mg/qm) and anti‐thymocyte globulin followed by allogeneic stem cell transplantation from related ( n = 8) and unrelated donors ( n = 13) in 21 patients with myelofibrosis. The median age of the patients was 53 years (range, 32–63). No primary graft failure occurred. The median time until leucocyte (>1·0 × 10 9 /l) and platelet (>20 × 10 9 /l) engraftment was 16 (range, 11–26) and 23 d (range, 9–139) respectively. Complete donor chimaerism on day 100 was seen in 20 patients (95%). Acute graft‐ versus ‐host disease (GvHD) grades II–IV and III/IV occurred in 48% and 19% of cases and 55% of the patients had chronic GvHD. Treatment‐related mortality was 0% at day 100 and 16% [95% confidence interval (CI): 0–32%] at 1 year. Haematological response was seen in 100% and complete histopathological remission was observed in 75% of the patients and 25% of the patients showed partial histopathological remission with a continuing decline in the grade of fibrosis. After a median follow‐up of 22 months (range, 4–59), the 3‐year estimated overall and disease‐free survival was 84% (95% CI: 67–100%).