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Association of NAT and GST polymorphisms with non‐Hodgkin's lymphoma: a population‐based case–control study
Author(s) -
Chiu Brian C.H.,
Kolar Carol,
Gapstur Susan M.,
Lawson Terence,
Anderson James R.,
Weisenburger Dennis D.
Publication year - 2005
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2004.05358.x
Subject(s) - nat , lymphoma , association (psychology) , oncology , medicine , hodgkin lymphoma , genetics , biology , psychology , statistics , mathematics , psychotherapist
Summary Several chemicals have been associated with risk of non‐Hodgkin's lymphoma (NHL), many of which are substrates for N‐acetyltransferase (NAT) and glutathione S‐transferase (GST) enzymes. We investigated the association between polymorphisms in genes coding for these enzymes and NHL risk in a population‐based study (389 cases and 535 controls). NAT1 slow genotype was associated with a slightly increased risk in women [odds ratios (OR) = 1·4; 95% confidence interval (CI) = 0·9–2·3], but not in men. NAT2 slow genotype was not associated with risk in either sex. The two slow genotypes of NAT1 and NAT2 combined were associated with a minor increase of risk in women (OR = 1·4; 0·8–2·4). There was no association with the GSTM1 or GSTT1 null genotype in either sex, irrespective of histological subtypes. Individuals with GSTP1 Val homozygotes had non‐significant excessive risk of marginal zone lymphoma (OR = 1·8; 0·6–5·1) and ‘other’ B‐cell NHLs (OR = 1·6; 0·7–3·6), but lower risk of diffuse large B‐cell lymphoma (OR = 0·2; 0·1–0·96). Risk did not elevate with an increasing number of high‐risk GST alleles in either sex. In summary, although NAT1 , NAT2 , GSTM1 , GSTT1 , or GSTP1 polymorphisms do not appear to be associated with NHL risk overall, there might be gender‐specific and subtype‐specific associations that require confirmation.