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Inactivation of parvovirus B19 by liquid heating incorporated in the manufacturing process of human intravenous immunoglobulin preparations
Author(s) -
Yunoki Mikihiro,
Urayama Takeru,
Tsujikawa Muneo,
Sasaki Yoshie,
Abe Shunichi,
Takechi Kazuo,
Ikuta Kazuyoshi
Publication year - 2005
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2004.05309.x
Subject(s) - parvovirus , virus inactivation , parvoviridae , antibody , manufacturing process , human plasma , immunoglobulin g , chemistry , chromatography , virus , medicine , virology , immunology , materials science , composite material
Summary Several reports have suggested the possible transmission of human parvovirus B19 (B19) through the administration of plasma derivatives that had undergone virus inactivation by various types of heat treatment. However, none of the reports evaluated and discussed the inactivation of B19 by the heat treatment that is implemented in the individual manufacturing processes of such products. The present study evaluated the ability to inactivate B19 of liquid‐heat treatment at 60°C for 10 h that was incorporated in the manufacturing process of intravenous human immunoglobulin preparations. The results showed that B19 was rapidly inactivated under the conditions used for the liquid‐heat treatment.