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TAFI polymorphisms at amino acids 147 and 325 are not risk factors for cerebral infarction
Author(s) -
Akatsu Hiroyasu,
Yamagata Hidehisa,
Chen Yusen,
Miki Tetsuro,
Kamino Kouzin,
Takeda Masatoshi,
Campbell William,
Kondo Ikuko,
Kosaka Kenji,
Yamamoto Takayuki,
Okada Hidechika
Publication year - 2004
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2004.05219.x
Subject(s) - medicine , allele , zymogen , gastroenterology , cerebral infarction , amino acid , fibrinolysis , polymorphism (computer science) , population , statistical significance , allele frequency , endocrinology , biology , genetics , enzyme , biochemistry , ischemia , gene , environmental health
Summary Thrombin‐activatable fibrinolysis inhibitor (TAFI) was reported as an anaphylatoxin‐inactivating enzyme generated by proteolytic cleavage of its zymogen, and is the same enzyme as that first designated by our group as procarboxypeptidase R (proCPR). Its level in plasma appears to influence vascular disease. In addition, TAFI activity is strongly influenced by genetic polymorphism, especially at amino acids 147 and 325. We investigated whether these TAFI polymorphisms would act as a risk factor for cerebral infarction (CI) by examining 253 samples in which the diagnosis was cliniconeuropathologically confirmed. We found little that was statistically significant in terms of these polymorphisms among patients with no vascular problems or in a population‐based control group. In the present study of an elderly Japanese group, our samples revealed a lower percentage of the Ile allele at Thr/Ile‐325 compared with western counterparts. Although patients with severe infarcts had a lower percentage of the Ile allele (10%) at amino acid position 325 compared with the slightly and moderately affected patients and the population‐based control group (15–18%), no statistical significance was found. None of our results showed any statistical correlation between TAFI polymorphisms and CI.