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Human bone marrow adipocytes support complete myeloid and lymphoid differentiation from human CD34 + cells
Author(s) -
Corre Jill,
PlanatBenard Valérie,
Corberand Joël X.,
Pénicaud Luc,
Casteilla Louis,
Laharrague Patrick
Publication year - 2004
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2004.05198.x
Subject(s) - cd34 , mesenchymal stem cell , haematopoiesis , bone marrow , myeloid , progenitor cell , stromal cell , stem cell , microbiology and biotechnology , biology , cellular differentiation , progenitor , adipogenesis , immunology , cancer research , biochemistry , gene
Summary In humans, the role of bone marrow (BM) adipocytes in supporting haematopoiesis has been questioned. A co‐culture system of CD34 + cells seeded onto either BM undifferentiated mesenchymal stem cells or differentiated adipocytes showed that BM adipocytes did not support the maintenance of immature progenitors but enabled their complete differentiation along the myeloid and lymphoid pathways. These properties appear to be opposite to those of osteoblasts, although both cell types share a common mesenchymal progenitor. These results suggest that stromal cells play a variety of roles in the haematopoietic microenvironment, which could be significant in situations such as osteoporosis or ageing.