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P‐selectin in haemostasis
Author(s) -
André Patrick
Publication year - 2004
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2004.05032.x
Subject(s) - thrombosis , inflammation , platelet , p selectin , immunology , medicine , platelet activation , selectin , endothelium , endothelial stem cell , microbiology and biotechnology , biology , in vitro , biochemistry
Summary During the past decade, interrelationships between inflammation and thrombosis have been the subject of extensive works, and it is now commonly recognized that inflammation (notably leucocyte recruitment) directly affects thrombosis, and that thrombosis also constitutes a pro‐inflammatory event. This tight link is partly attributable to P‐selectin, which is functional not only when expressed on the surface of activated platelets and endothelial cells, but also when shed, generating its soluble form, termed sP‐selectin. In this review, we will provide an overview of the relative roles of the different compartments of P‐selectin (platelet, endothelial cell, plasma) in haemostasis and vascular pathologies, and the potential therapeutic benefits achievable in targeting this molecule.