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Haematogones in the peripheral blood of adults: a four‐colour flow cytometry study of 102 patients
Author(s) -
Kroft Steven H.,
Asplund Sheryl L.,
McKenna Robert W.,
Karandikar Nitin J.
Publication year - 2004
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2004.05011.x
Subject(s) - medicine , peripheral blood , flow cytometry , bone marrow , pathology , lymphoma , peripheral , minimal residual disease , follicular lymphoma , stage (stratigraphy) , gastroenterology , nuclear medicine , biology , immunology , paleontology
Summary Haematogones have been extensively characterized in bone marrow, but not in the peripheral blood (PB). We studied 102 PB samples from adult patients with a sensitive flow cytometry method. Sixty‐six of 102 samples (65%) contained detectable haematogones, ranging from 0·01% to 1·3% of white blood cells (median 0·06%, mean 0·13%). Of 66 cases with complete blood count data, 51 had absolute haematogone counts of 0·00037–0·105 × 10 9 /l (median 0·0054 × 10 9 /l, mean 0·012 × 10 9 /l). PB haematogones belonged exclusively to the most mature maturational stage. These findings have implications for PB analysis of minimal residual disease in acute lymphoblastic leukaemia and follicular lymphoma.