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Variant MYST4‐CBP gene fusion in a t(10;16) acute myeloid leukaemia
Author(s) -
Murati Anne,
Adélaïde José,
Mozziconacci MarieJoëlle,
Popovici Cornel,
Carbuccia Nadine,
Letessier Anne,
Birg Françoise,
Birnbaum Daniel,
Chaffanet Max
Publication year - 2004
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2004.04960.x
Subject(s) - exon , myeloid leukaemia , fusion gene , fusion protein , biology , gene , microbiology and biotechnology , myeloid , cancer research , genetics , recombinant dna
Summary We report a novel fusion of the MYST4 and CBP genes in an acute myeloid leukaemia (AML)‐M4 patient exhibiting t(10;16)(q22;p13) and t(11;17)(q23;q21). The t(10;16)(q22;p13) resulted in a rearrangement, where MYST4‐CBP and CBP‐MYST4 chimaeric transcripts were products of in‐frame fusions of MYST4 exon 17 to CBP exon 6 and CBP exon 4 to MYST4 exon 18 respectively. The potential resulting chimaeric proteins showed similarities with MYST3‐CBP, MYST3‐P300 and MYST3‐NCOA2 putative fusion proteins found in other cases of AML.