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Moderate hypoxia suppresses exercise‐induced procoagulant changes
Author(s) -
DeLoughery Thomas G.,
Robertson Deborah G.,
Smith Cristina A.,
Sauer David
Publication year - 2004
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2004.04924.x
Subject(s) - hypoxia (environmental) , fibrinolysis , antithrombotic , exertion , medicine , plasminogen activator , tissue plasminogen activator , physical exercise , activator (genetics) , endocrinology , plasminogen activator inhibitor 1 , chemistry , oxygen , receptor , organic chemistry
Summary Hypoxia has been implicated as a stimulant of coagulation. As exertion is known to affect haemostasis, we sought to control for this by using a standardized protocol. Subjects were exercised both at room air and at 12% oxygen. Exercise produced an increase in procoagulant factors, which was reduced with hypoxic exercise. Room air exercise increased fibrinolytic markers. Hypoxic exercise did not affect the increase in tissue plasminogen activator, but decreased the increase in plasminogen activator inhibitor‐1 expression. Thus, it appears that hypoxia may exert an antithrombotic effect by both damping exercise‐induced procoagulant changes and stimulating fibrinolysis.