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α ‐Galactosylceramide‐driven expansion of human natural killer T cells is inhibited by prednisolone treatment
Author(s) -
Johansson Ulrika,
Macey Marion G.,
Kenny Deborah,
Provan Drew,
Newland Adrian C
Publication year - 2004
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2004.04896.x
Subject(s) - natural killer t cell , prednisolone , immunology , immune system , medicine , autoimmune disease , natural killer cell , t cell , biology , in vitro , antibody , cytotoxic t cell , biochemistry
Summary The mechanisms of action of most treatments in the autoimmune disorders are unclear and steroids remain the first‐line therapy in these diseases. Natural killer T (NKT) cell activity has been implicated in the autoimmune process but whether steroids act via an affect on NKT cell function, such as antigen‐specific proliferative capacity, is unknown. Immune thrombocytopenia (ITP) patients were studied ex vivo for NKT cell expansion in response to the specific NKT cell antigen, α ‐galactosylceramide, before, during or after prednisolone treatment. Prednisolone inhibited antigen‐specific NKT cell expansion in ITP patients in remission. Untreated ITP patients also showed reduced NKT cell proliferative capacity, although this was less marked than in treated patients. These results support a role for NKT cells in ITP and aid understanding of the immunosuppressive activities of prednisolone in autoimmune disease.