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Chromosome 13 abnormalities in multiple myeloma are mostly monosomy 13
Author(s) -
AvetLoiseau Hervé,
Daviet Axelle,
Saunier Stéphanie,
Bataille on behalf of the Intergroupe Francophone du Myélome Régis
Publication year - 2000
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2000.02488.x
Subject(s) - monosomy , fluorescence in situ hybridization , biology , chromosome 13 , chromosome abnormality , multiple myeloma , chromosome , locus (genetics) , cytogenetics , pathology , aneuploidy , genetics , karyotype , microbiology and biotechnology , medicine , gene , immunology
Chromosome 13 abnormalities are frequently observed in multiple myeloma (MM). Several reports recently demonstrated the strong prognostic value of these abnormalities, associated with a short survival. Cytogenetic studies have shown that most of these abnormalities are complete monosomies. In order to define the common minimal deletion, we analysed a series of 234 patients with MM using fluorescence in situ hybridization (FISH) with a panel of five probes mapping along the whole chromosome 13. A chromosome 13 abnormality was observed in 98 patients (42%), 90 of whom (92%) displayed a complete monosomy. In seven of the eight remaining patients presenting partial deletions, the three probes specific for the 13q14 region were deleted. Only one patient (1%) displayed a small deletion of the D13S319 locus. In conclusion, FISH should be used for the analysis of chromosome 13 abnormalities, using probes mapping in the 13q14 region.