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Engraftment of T‐cell‐depleted allogeneic haematopoietic stem cells using a reduced intensity conditioning regimen
Author(s) -
Craddock C.,
Bardy P.,
Kreiter S.,
Johnston R.,
Apperley J.,
Marks D.,
Huber C.,
Kolbe K.,
Goulding R.,
Lawler M.,
Goldman J.,
Hughes T.,
Derigs G.
Publication year - 2000
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2000.02454.x
Subject(s) - medicine , conditioning regimen , regimen , fludarabine , stem cell , transplantation , graft versus host disease , haematopoiesis , hematopoietic stem cell transplantation , surgery , oncology , immunology , chemotherapy , cyclophosphamide , biology , genetics
Graft‐versus‐host disease (GVHD) remains a significant complication in patients undergoing allogeneic stem cell transplantation (SCT) using a reduced intensity conditioning regimen. Although T‐cell depletion (TCD) reduces the risk of GVHD after a myeloablative conditioning regimen, it is associated with an increased risk of graft failure. We have therefore examined whether TCD compromises engraftment using a fludarabine‐based conditioning regimen. Fifteen patients have been transplanted using such a regimen of whom 13 underwent ex vivo TCD. All but one patient demonstrated durable engraftment and no patient receiving a TCD product developed severe GVHD. Thus, TCD may play a role in GvHD prophylaxis using such regimens.