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Is it necessary to administer anti‐D to prevent RhD immunization after the transfusion of RhD‐positive platelet concentrates?
Author(s) -
Atoyebi W.,
Mundy N.,
Croxton T.,
Littlewood T. J.,
Murphy M. F.
Publication year - 2000
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2000.02414.x
Subject(s) - immunization , medicine , platelet , isoantibodies , platelet transfusion , blood transfusion , immunology , virology , antibody
Serology for the presence of anti‐D after RhD‐incompatible platelet transfusions was performed in 24 RhD‐negative patients with haematological disease and 59 RhD‐negative patients with non‐haematological disease. None of the patients were given prophylaxis with anti‐D to prevent RhD immunization. Eight out of 59 (13·5%) non‐haematology patients developed detectable anti‐D, whereas 0 out of 24 (0%) of the haematology patients formed anti‐D ( P = 0·06). The risk of alloimmunization after RhD‐incompatible platelet transfusions using platelet concentrates prepared by modern technical methods appears to be small in patients with haematological disease, but is significant in non‐immunocompromised patients.