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The 8p12 myeloproliferative disorder. t(8;19)(p12;q13.3): a novel translocation involving the FGFR1 gene
Author(s) -
Mugneret Francine,
Chaffanet Max,
Maynadié Marc,
Guasch Géraldine,
Favre Bernardine,
Casasnovas Olivier,
Birnbaum Daniel,
Pébusque MarieJosèphe
Publication year - 2000
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2000.02355.x
Subject(s) - chromosomal translocation , locus (genetics) , fibroblast growth factor receptor 1 , biology , gene , genetics , cancer research , fibroblast growth factor , receptor
Translocations affecting the chromosomal locus 8p12 are hallmarks of an atypical stem cell myeloproliferative disorder. These events disrupt the fibroblast growth factor receptor 1 ( FGFR1 ) gene and fuse the FGFR1 C‐terminus catalytic domain with unrelated proteins. Here, we report on the characterization of the 19q13.3 locus as the fifth FGFR1 chromosomal partner.