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Endogenous serum levels of thrombopoietic cytokines in healthy whole‐blood and platelet donors: implications for plateletpheresis
Author(s) -
Tacke F.,
Schöffski P.,
Trautwein C.,
Martin M. U.,
Stangel W.,
Seifried E.,
Manns M. P.,
Ganser A.,
Petersen D.
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1999.01328.x
Subject(s) - thrombopoietin , plateletpheresis , platelet , thrombopoiesis , medicine , erythropoietin , interleukin 11 , whole blood , immunology , cytokine , interleukin , haematopoiesis , apheresis , megakaryocyte , biology , genetics , stem cell
Serum concentrations of the thrombopoiesis‐enhancing cytokines thrombopoietin (TPO), erythropoietin (EPO), interleukin (IL)‐6 and IL‐11 were determined in 119 healthy whole‐blood (WBD) and 101 platelet donors (PD) prior to donation. The 90% TPO reference interval in WBD of 64–867 pg/ml (median 163, 100% range 45–7572) was significantly higher than in PD of 56–524 (median 122, range 44–801, P = 0.004), whereas their platelet counts were lower ( P < 0.001). EPO levels were not different (WBD 7.7 ± 3.8, PD 8.0 ± 4.9 IU/l), IL‐6 and IL‐11 were below the detection limit in 90% of cases (IL‐6 < 3.2 pg/ml, IL‐11 < 31.2 pg/ml). None of the cytokines correlated with platelet counts, other blood parameters, or in the PD group with the frequency of platelet donations within the last 6 months. We conclude that plateletpheresis does not lead to a lasting increase of thrombopoietic cytokines and provide reference data for potential platelet mobilization strategies with recombinant growth factors.