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Two case studies of chronic idiopathic neutropenia preceding acute myeloid leukaemia
Author(s) -
Auner Holger,
Klintschar Michael,
Crevenna Richard,
BehamSchmid Christine,
Hoefler Gerald,
Mitterbauer Gerlinde,
Linkesch Werner,
Sill Heinz
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1999.01322.x
Subject(s) - neutropenia , congenital neutropenia , loss of heterozygosity , medicine , immunology , myeloid , malignant transformation , cancer research , gene , biology , chemotherapy , genetics , allele
Chronic idiopathic neutropenia is regarded as a benign disorder without risk of malignant transformation. We present two patients with chronic idiopathic neutropenia who showed disease progression to acute myeloid leukaemia. Sequence analysis of the granulocyte‐colony stimulating factor receptor (G‐CSFR) gene from leukaemic DNA did not reveal any mutations and microsatellite analysis provided no evidence of microsatellite instability or loss of constitutional heterozygosity. These case studies suggest that chronic idiopathic neutropenia may constitute a preleukaemic condition in some patients. Alterations of the G‐CSFR or defective DNA mismatch repair do not appear to be involved in malignant transformation.