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Human myeloma cells express the CD38 ligand CD31
Author(s) -
Vallario Antonella,
Chilosi Marco,
Adami Fausto,
Montagna Licia,
Deaglio Silvia,
Malavasi Fabio,
CaligarisCappio Federico
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1999.01321.x
Subject(s) - cd38 , multiple myeloma , cd31 , medicine , ligand (biochemistry) , cancer research , immunology , computational biology , biology , genetics , stem cell , angiogenesis , cd34 , receptor
Multiple myeloma (MM) plasma cells (PC) are CD38 + . A ligand for CD38 is the adhesion molecule CD31. By flow cytometry and immunocytochemistry we have investigated whether malignant PC co‐express CD38 and CD31. All 68 patients studied were CD38 + . 14/14 monoclonal gammopathies of undetermined significance (MGUS) and 39/39 plasmacytic MM patients co‐expressed CD38 and CD31 at high density. Only 1/11 plasmablastic MM and 1/4 plasma cell leukaemias (PCL) expressed CD31. These data indicated that PC malignancies co‐expressed high levels of both CD38 and its ligand CD31, with the exception of plasmablastic MM and PCL.