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High numbers of clonal CD19 + cells in the peripheral blood of a patient with multiple myeloma
Author(s) -
Rasmussen Thomas,
Kastrup Jesper,
Knudsen Lene Meldgaard,
Johnsen Hans Erik
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1999.01301.x
Subject(s) - clone (java method) , multiple myeloma , cd19 , population , progenitor cell , cd34 , immunology , somatic evolution in cancer , biology , peripheral blood , microbiology and biotechnology , stem cell , medicine , genetics , cancer , gene , environmental health
Recent studies concerning the numbers of circulating clonal B cells in patients with multiple myeloma (MM) have reported conflicting data regarding the exact levels of clonal B cells and the existence of clonal cells in the CD34 compartment. In this report we show that high numbers of clonal cells with a phenotype of late‐stage B cells or pre‐plasma cells were present in the peripheral blood (PB) of a patient with MM. During treatment the initial high level of PB clonal cells was markedly reduced and remained low (<1%) post transplant, even after disease progression. In addition, we found that the MM clone did not include a B‐progenitor population defined by CD34.