Premium
Paraproteins and monoclonal expansion of CD3 + CD8 + CD56 − CD57 + T lymphocytes in a patient with HIV infection
Author(s) -
Smith Penelope,
Helbert Matthew,
Raftery Martin,
Forster Greta,
Cavenagh Jamie
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1999.01293.x
Subject(s) - paraproteins , isotope , radiochemistry , monoclonal antibody , physics , chemistry , monoclonal , medicine , nuclear physics , antibody , immunology
An expansion of CD8 + lymphocytes associated with a monoclonal rearrangement of the T‐cell receptor γ locus was found in a woman with HIV‐1 infection. A subpopulation of HIV‐positive patients display an unusual response to HIV infection characterized by a persistent marked CD8 + lymphocytosis, the presence of which appears to be associated with an improved long‐term prognosis. This condition is thought to represent a florid immune response to an ongoing viral infection which may be HIV itself, and suggests that monoclonal proliferation of CD8 + lymphocytes does not imply the presence of an underlying malignant process.