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Absence of hepatitis A virus transmission by high‐purity solvent detergent treated coagulation factor concentrates in Scottish haemophiliacs
Author(s) -
Watson Henry G.,
Ludlam Christopher A.,
McOmish Fiona,
Dennis Rosemary,
Hart Helena,
Simmonds Peter
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb08935.x
Subject(s) - medicine , seroconversion , virology , hepatitis a virus , haemophilia , seroprevalence , haemophilia a , hepatitis a , virus , hepatitis , immunology , pediatrics , antibody , serology
Summary. Recent reports of hepatitis A virus (HAV) infection in haemophiliacs receiving high‐purity solvent detergent (HP.SD) treated factor VIII concentrates have brought into question the efficacy of this virucidal method for inactivating HAV. To assess whether HAV may have been transmitted by HP.SD concentrates, we compared seroprevalence in haemophiliacs with different disease severity, sought evidence of seroconversion to HAV since introduction of HP.SD products, and directly examined concentrates for HAV RNA by PCR. Our data suggest that Scottish haemophiliacs are not being infected with HAV by HP.SD concentrates produced initially by CRTS Lille and presently by PFC Edinburgh and supplied by the Scottish National Blood Transfusion Service (SNBTS).