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Cytomegalovirus‐induced T‐cell proliferation and the development of progressive multifocal leucoencephalopathy following bone marrow transplantation
Author(s) -
Owen R. G.,
Patmore R. D.,
Smith G. M.,
Barnard D. L.
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb08930.x
Subject(s) - cytomegalovirus , medicine , immunology , transplantation , jc virus , progressive multifocal leukoencephalopathy , bone marrow transplantation , slow virus , pathology , bone marrow , herpesviridae , virology , viral disease , virus
Summary. Progressive multifocal leucoencephalopathy (PML) is a rare disorder characterized by progressive demyelination within the brain. It is usually fatal and occurs when there are defects in cell‐mediated immunity. We report a case of PML which developed following allogeneic bone marrow transplantation. It was preceded by the development of a persistent polyclonal expansion of large granular lymphocytes (LGLs) which appeared to rise as a consequence of cytomegalovirus infection.