Premium
Osteoporosis in severe congenital neutropenia treated with granulocyte colony‐stimulating factor
Author(s) -
Bishop N. J.,
Williams D. M.,
Compston J. C.,
Stirling D. M.,
Prentice A.
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb08441.x
Subject(s) - neutropenia , medicine , congenital neutropenia , osteoporosis , granulocyte colony stimulating factor , granulocyte , pediatrics , chemotherapy
Recombinant human granulocyte colony‐stimulating factor (G‐CSF) has substantially improved life expectancy for children with severe congenital neutropenia (SCN). Severe osteoporosis, reported in this population, may relate to the disease process, or be a therapeutic side‐effect. This report details bone loss, quantitated absorptiometrically and histomorphometrically, in a child with SCN and vertebral collapse, and the positive response to anabolic steroid and bisphosphonate therapy.