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Correction of anaemia and thrombocytopenia in a case of adult Type I osteopetrosis with recombinant human erythropoietin (rHuEPO)
Author(s) -
Meletis John,
Samarkos Michalis,
Michali Evi,
Vavourakis Stathis,
Meletis Christos,
Poziopoulos Christos,
Stavrogianni Niki,
Konstantopoulos Kostas,
Vaiopoulos George,
Yataganas Xenophon,
Loukopoulos Dimitris
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb08436.x
Subject(s) - osteopetrosis , erythropoietin , medicine , haematopoiesis , recombinant dna , anemia , erythropoiesis , stem cell , biology , biochemistry , genetics , gene
A case of adult osteopetrosis Type I was diagnosed in a 22‐year‐old female. She presented for investigation of anaemia with ‘myelophthisic’characteristics and extramedullary haemopoiesis which was resistant to haematinics, nandrolone and low‐dose corticosteroids. She became progressively transfusion‐dependent with gradually worsening thrombocytopenia. She was successfully treated with recombinant erythropoietin. Anaemia as well as thrombocytopenia were corrected. There appeared to be a synergistic action of erythropoietin with steroids.