Premium
Familial thrombocytosis
Author(s) -
Kikuchi M.,
Tayama T.,
Hayakawa H.,
Takahashi I.,
Hoshino H.,
Ohsaka A.
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb08432.x
Subject(s) - thrombocytosis , proband , bone marrow , platelet , pathology , medicine , bone marrow examination , lymphoma , karyotype , chromosome , immunology , biology , genetics , gene , mutation
Four cases of thrombocytosis in three successive generations of a family are described. High peripheral platelet count was found incidentally in the proband with cutaneous malignant lymphoma. Bone marrow examination showed megakaryocytic hyperplasia. Neither Philadephia chromosome nor chimaeric bcr/abl junction was detected in marrow cells. In this family, thrombocytosis was thought to be transmitted by an autosomal dominant mode of inheritance.