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Detection of monoclonal plasma cells in the peripheral blood stem cell harvests of patients with multiple myeloma
Author(s) -
Witzig Thomas E.,
Gertz Morie A.,
Pineda Alvaro A.,
Kyle Robert A.,
Greipp Philip R.
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb08378.x
Subject(s) - apheresis , multiple myeloma , monoclonal , monoclonal antibody , peripheral blood , immunofluorescence , medicine , stem cell , plasma cell , pathology , immunology , biology , platelet , antibody , genetics
We evaluated the harvest product from 47 patients undergoing peripheral blood (BP) stem cell collections for monoclonal plasma cells (PC) using a sensitive immunofluorescence technique. 60% (28/47) had docu mented tumour cells in the apheresis product. The 32 patients in plateau had a mean of 1.62 x 10 6 PC/1 v 74.64 x 10 6 in 15 relapsed patients ( P < 0.01). 32% (6/19) of patients without any tumour cells in the initial sample had them detected on a subsequent apheresis sample. In four cases (all treated with GM‐CSF) small numbers of tumour cells were detected initially but became undetectable on a subsequent sample.