Epinephrine test and plasma elastase as diagnostic tools in a patient with CD3 +  large granular lymphocyte proliferation | Zendy

Seebach Jörg | Zendy; Schleiffenbaum Boris | Zendy; Rüegg Regula | Zendy; Fehr Jörg | Zendy

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Epinephrine test and plasma elastase as diagnostic tools in a patient with CD3 + large granular lymphocyte proliferation

Author(s) -

Seebach Jörg,

Schleiffenbaum Boris,

Rüegg Regula,

Fehr Jörg

Publication year - 1995

Publication title -

british journal of haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.907

H-Index - 186

eISSN - 1365-2141

pISSN - 0007-1048

DOI - 10.1111/j.1365-2141.1995.tb08375.x

Subject(s) - neutropenia , epinephrine , cd3 , cd8 , neutrophil elastase , lymphocyte , medicine , immunology , elastase , t lymphocyte , endocrinology , pathology , immune system , biology , chemotherapy , inflammation , biochemistry , enzyme

Large granular lymphocytes (LGL) proliferation is characterized by expansion of cytotoxic lymphocytes and associated with neutropenia. In a case of CD3 + LGL‐proliferation the epinephrine stimulation test (EST) induced a striking elevation of CD3 + , CD8 + , CD57 + LGL in peripheral blood from 2.7 x 10 9 /1 to 20 x 10 9 /1 and might be an additional diagnostic tool in patients with normal or low absolute numbers of circulating LGL. After treatment with steroids, plasma elastase ‐ a marker of neutrophil destruction ‐ decreased from 162 to 40μg/1 (normal < 47μg/1) which correlated well with a simultaneous increase in peripheral neutrophil counts from 0.14 to 1.0 x 10 9 /1. This finding supports the hypothesis that neutropenia in CD3 + LGL proliferation is due to neutrophil destruction, possibly mediated by LGL.

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