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Expression of granulocyte colony‐stimulating factor receptor on CD10‐positive human B‐cell precursors
Author(s) -
Inukai Takeshi,
Sugita Kanji,
Iijima Kiyomu,
Tezuka Toru,
Goi Kumiko,
Kojika Satoru,
Shiraishi Kyoko,
Kagami Keiko,
Nakazawa Shinpei
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb08373.x
Subject(s) - granulocyte colony stimulating factor , granulocyte , cancer research , receptor , medicine , chemistry , chemotherapy
We examined the expression of CD10 and G‐CSF receptor (G‐CSFR) on the lymphoid population of mononuclear cells obtained from bone marrow (BM) using two‐colour analysis. In the BM of children with ALL in remission, the CD10 + population was significantly increased (20.6 ± 5.1% compared with that of controls (2.5 ± 0.5%). More than half (61.3 ± 2.9%) of the CD10 + cells coexpressed G‐CSFR, but not CD13. These results indicate G‐CSFR + B‐cell precursors are markedly increased in BM of ALL in remission, suggesting the probable involvement of G‐CSF in the human early B‐cell ontogeny.