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Flow cytometric determination of pre‐transfusion red cell volume in fetuses and neonates requiring transfusion based on RhD + dilution by transfused D ‐ red cells
Author(s) -
Wynn R.,
Dixon S.,
AlIsmail S. A.,
Jones J. G.,
Fisher J.,
Hoy T.,
Dawson A.,
Wardrop C. A. J.
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb08372.x
Subject(s) - medicine , red cell , exchange transfusion , fetus , dilution , red blood cell , obstetrics , pediatrics , immunology , pregnancy , biology , genetics , physics , thermodynamics
We report a case of feto‐maternal haemorrhage and describe a new flow‐cytometric method of determining a fetus's or infant's pre‐transfusion red cell volume (RCV). We validate this method against an established technique, employing fetal haemoglobin (HbF) dilution, for determining the RCV in fetuses and neonates requiring intravascular transfusion. We discuss advantages and other potential applications of this new method.