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Emergence of karyotypically unrelated clone in remission of de novo acute myeloblastic leukaemias
Author(s) -
Kudoh Shiori,
Asou Hiroya,
Kyo Taiichi,
Asaoku Hideki,
Dohy Hiroo,
Eguchi Mariko,
Tashiro Satoshi,
Tanaka Kimio,
Kamada Nanao
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb08359.x
Subject(s) - clone (java method) , complete remission , acute myeloblastic leukemia , bone marrow , cytogenetics , karyotype , biology , medicine , chromosome , oncology , immunology , gastroenterology , genetics , leukemia , chemotherapy , gene
Serial cytogenetic analysis revealed karyotypically unrelated clones in four patients with acute myeloblastic leukaemia (AML) in remission. At diagnosis, three patients had t(8;21)(q22;q22) and one had an inv(16)(p13q22). After 18‐22 months in remission, different clones emerged in each patient with myelodysplastic features of the bone marrow cells. The emergence of clones with abnormalities of chromosome 7 in remission seems to be an unfavourable factor for prognosis.